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Organic Acids- Methylation Cofactors (Test Code 4018)

Collection Method

Spot Urine

Turn Around Time

12 business days

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The organic acids test is a simple urine test that looks at biomarkers from various metabolic pathways. Methylation as a biochemical process in the human body is critical for many physiological processes. The foundational functions of methylation, donation of a carbon and 3 hydrogens include gene mutations, neurotransmitter synthesis, and metabolism of folic acid, b-group vitamins, protein metabolism, liver detoxification, and homocysteine metabolism.

Methylation is responsible for:

• The stress (fight-or-flight) response
• Glutathione production
• Genetic expression and the repair of DNA
• Neurotransmitter production and metabolism
• Protection against free radicals
• Energy production
• Immune support protecting against infections

The methylation cofactors panel evaluates methylmalonate and Formiminoglutamate levels. Elevations of methylmalonate is associated with Vitamin B12 deficiency as it is required as a cofactor for conversion of methylmalonate to succinyl-CoA.

Formiminoglutamate (FIGLU) is made from the amino acid, Histidine. Elevated levels of FIGLU is associated with a deficiency of folic acid. Folic acid is especially critical for prenatal and childhood development.

Common Conditions:

• Cancer
• Depression
• Fatigue
• Cognitive decline
• Autism
• Infertility/miscarriage
• Preconception care
• Mental health disorders
• Cardiovascular disease
• High folate supplementation

Krebs/Citric Acid Cycle (Test Code: 4013)

Lactic acid, Pyruvic acid, Citric acid, cis-aconitic acid, Isocitric acid, α-ketoglutaric acid, Fumaric acid, Malic acid.

Environmental Pollutants (Test Code: 4014)

Metabolites of Benzene, Xylene, Toluene, Trimethylbenzene, Styrene, Phthalate exposure.

Ketone/Fatty Acid Metabolites (Test Code: 4015)

Adipic acid, Suberic acid, β-hydroxy-β-methyglutaric acid (HMG), β-hydroxybutyric acid.

Metabolic Profile (Test Code: 4016)

Organic acids for Intestinal dysbiosis (i.e. Test Code: 2013), Citric acid cycle metabolites (i.e. Test Code: 4013), Ketone/fatty acid metabolites (i.e. Test Code: 4015), Cofactor sufficiency markers, Neurotransmitter metabolites (HVA, VMA, 5HIAA).

Metabolic & Environmental Pollutants (Test Code: 4017)

Organic acids for Intestinal dysbiosis (i.e. Test Code: 2013), Citric acid cycle metabolites (i.e. Test Code: 4013), Ketone/fatty acid metabolites (i.e. Test Code: 4015), Cofactor sufficiency markers, Neurotransmitter metabolites (HVA, VMA, 5HIAA) AND Environmental Pollutants (i.e. Test Code: 4014)

Test Method

Liquid chromatography–mass spectrometry (LC-MS/MS)

Analytes

Formiminoglutamic acid (FIGLU), Methylmalonic acid (MMA)

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NutriPATH practices in the usual practitioner-referral system for pathology laboratories.Patients are highly recommended to seek the supervision and guidance of a qualified healthcare practitioner for the interpretation of any lab results and associated information. NutriPATH can offer assistance in locating a suitable practitioner

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