Histamine intolerance is mainly caused by an imbalance of histamine intake and the capacity for histamine metabolism and degradation. The main enzyme for metabolism of ingested histamine is diamine oxidase (DAO). Determination of DAO activity in serum might be useful for differential diagnosis of histamine intolerance.
A cause of histamine intolerance may be drugs, which are inhibitors of the diamine oxidase. Alcohol and its degradation product acetaldehyde are inhibitors too. Additionally yet unknown effects on the activation of isoforms may have influence on the histamine-degrading capacity.
- Menstrual pain
- Dry nose
- Skin Conditions