Mast Cell Activation Syndrome (MCAS) is a condition where a patient may have a normal level of mast cells present, but these cells may be over-responsive or overreact to the body. Symptoms are usually related to the excess and episodic release of inflammatory mediators from mast cells. A common presentation is recurrent anaphylaxis where no trigger or cause can be identified. It is often a challenging condition to detect because the inflammatory mediators may only be released during an episode, then return to normal levels. For example, if the patient is amidst a flare-up they may or may not have an elevated serum tryptase level.
NutriPATH have three panels available for MCAS assessment.
The MCAS Profile – Basic Code 3409 includes some of the basic inflammatory mediators that may be released in Mast Cell Activation syndrome. For example, these include Tryptase, Chromogranin A, Whole Blood Histamine. Tryptase is a serine protease that is released during mast cell degranulation. Chromogranin A is another inflammatory mediator used to identify MCAS.
The MCAS Profile- Extensive Code 3410 assesses in a urine sample Prostaglandin D2, Leukotriene E4 and 2,3 Dinor-11b-Prostaglandin F2a. Prostaglandin D2 is a major inflammatory mediator produced by Mast Cells. Leukotriene E4 is also one of the inflammatory molecules that could be released by mast cells during an attack or flare up. 2,3 dinor-11beta-prostaglandin F2-alpha is a marker used in the screening of Mast cell activation disorders. N-methyl-histamine is a major histamine metabolite which is produced in the mast cells. Excess levels are seen in Mast Cell Activation Syndrome.
The MCAS Profile Advanced Code 3411 assesses all analytes in 3409 and 3410 as well as Diamone Oxidase and Total IgE. Diamine Oxidase is the enzyme responsible for clearing histamine in the body and excess histamine may be related to dysfunctional diamine oxidase. Total IgE test measures the amount of IgE antibody in the blood. Allergies are a common condition that affects the body’s immune system. When the body has an allergic reaction, a normally harmless trigger substance such as dust, pollen or specific foods, initiates an immune response via production of an antibody called immunoglobulin IgE. A high detection of Total IgE in a blood sample may mean there are one or more allergies. This test measures the total number of IgE antibodies in the blood, which differs from the specific IgE test that measures IgE responses to various allergens. Total IgE may be elevated in MCAS patients.
- Itching (pruritus)
- Skin Flushing ie. skin turning red
- Shortness of breath
- Heart symptoms (low blood pressure, rapid heart rate)