The organic acids test is a simple urine test that looks at biomarkers from various metabolic pathways. Methylation as a biochemical process in the human body is critical for many physiological processes. The foundational functions of methylation, donation of a carbon and 3 hydrogens include gene mutations, neurotransmitter synthesis, and metabolism of folic acid, b-group vitamins, protein metabolism, liver detoxification, and homocysteine metabolism.
Methylation is responsible for:
• The stress (fight-or-flight) response
• Glutathione production
• Genetic expression and the repair of DNA
• Neurotransmitter production and metabolism
• Protection against free radicals
• Energy production
• Immune support protecting against infections
The methylation cofactors panel evaluates methylmalonate and Formiminoglutamate levels. Elevations of methylmalonate is associated with Vitamin B12 deficiency as it is required as a cofactor for conversion of methylmalonate to succinyl-CoA.
Formiminoglutamate (FIGLU) is made from the amino acid, Histidine. Elevated levels of FIGLU is associated with a deficiency of folic acid. Folic acid is especially critical for prenatal and childhood development.
• Cognitive decline
• Preconception care
• Mental health disorders
• Cardiovascular disease
• High folate supplementation